哺乳類精子ファクターとホスホリパーゼCゼータ

• Oda Shoji

  Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo

書誌事項

タイトル別名

• Mammalian Sperm Factor and Phospholipase C Zeta

抄録

In mammals, eggs exhibit a series of transient increases in intracellular calcium ion (Ca²⁺) concentrations (Ca²⁺ oscillations) at the time of fertilization, which are prerequisite and sufficient for egg activation. Recent studies have been revealing the molecular mechanism of how sperm induce Ca²⁺ oscillations in fertilized eggs, that has remained unclear for a longtime. Especially in mammals, the sperm factor theory is being confirmed, which postulates that a cytoplasmic factor in the spermatozoon (the "sperm factor") is introduced into the egg through the sperm-egg cytoplasmic connection and activates the egg. In 2002, a new isoform of phospholipase C (PLC), PLC zeta, was identified as a strong candidate for the mammalian sperm factor. In this mini-review, the history of the mammalian sperm factor theory and the search for the mammalian sperm factor is reviewed. In addition, whether PLC zeta is truly the mammalian sperm factor or not is discussed.<br>

収録刊行物

• 日本哺乳動物卵子学会誌

  日本哺乳動物卵子学会誌 23 (1), 2-9, 2006

  日本卵子学会

キーワード

• Fertilization
• Calcium
• Oscillations
• Sperm
• Phospholipase

詳細情報

• CRID: 1390282679315473024
• NII論文ID: 10017429056
• NII書誌ID: AN10548943
• DOI: 10.1274/jmor.23.2
• ISSN: 13475878
• ISSN: 13417738
• NDL書誌ID: 7954074
• Web Site: https://agriknowledge.affrc.go.jp/RN/2010724394
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7954074
• 本文言語コード: en
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