生理活性物質の全合成とその実践的展開の重要性  [in Japanese] Total Syntheses of Useful Bioactive Compounds and Significance of their Developments  [in Japanese]

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Author(s)

Abstract

Herein are described the first total syntheses of some bioactive compounds, which have been accomplished in my laboratories by a variety of strategies and methodologies to clarify their structure-activity relationships and to create practically useful lead compounds for new medicines. The target molecules are antibiotics (tylosin, oleandomycin and tetracycline), antifungals (nanaomycin D and kalafungin), antitumors (lymphostin and BE-54238 B), glycosidase inhibitors (cyclophellitol and nagstatin), peptidase inhibitors (pyrizinostatin, antipain and chymostatin), nervous systemaffecting products (deacetyl-caloporoside, calbistrin A and ES-242-4), mussel-attachment inhibitors (sideroxylonal B and C), anti-pylori (PC-3 and YM-30059), TPO receptor agonist (xanthocillin X dimethylether), and so on.

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 64(5), 458-470, 2006-05-01

    The Society of Synthetic Organic Chemistry, Japan

References:  46

Codes

  • NII Article ID (NAID)
    10017486563
  • NII NACSIS-CAT ID (NCID)
    AN0024521X
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    00379980
  • NDL Article ID
    7959935
  • NDL Source Classification
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL Call No.
    Z17-256
  • Data Source
    CJP  NDL  J-STAGE 
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