The Homeostasis Model Assessment-insulin Resistance Index Is Inversely Associated with Serum Carotenoids in Non-diabetic Subjects

DOI Web Site PubMed 被引用文献27件 参考文献57件
  • Sugiura Minoru
    Department of Citrus Research, National Institute of Fruit Tree Science.
  • Nakamura Mieko
    Department of Epidemiology, National Institute for Longevity Sciences.
  • Ikoma Yoshinori
    Department of Citrus Research, National Institute of Fruit Tree Science.
  • Yano Masamichi
    Department of Citrus Research, National Institute of Fruit Tree Science.
  • Ogawa Kazunori
    Department of Citrus Research, National Institute of Fruit Tree Science.
  • Matsumoto Hikaru
    Department of Citrus Research, National Institute of Fruit Tree Science.
  • Kato Masaya
    Department of Citrus Research, National Institute of Fruit Tree Science.
  • Ohshima Makoto
    Department of Citrus Research, National Institute of Fruit Tree Science.
  • Nagao Akihiko
    Food Materials Research Division, National Food Research Institute.

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BACKGROUND: Carotenoids may reduce the risk for diabetes mellitus, but little is known about the association of insulin resistance with serum carotenoids in non-diabetic subjects. This study aimed to investigate whether the homeostasis model assessment-insulin resistance (HOMA-IR) index would be lower in the presence of high serum carotenoid concentrations in non-diabetic subjects.<br>METHODS: A total of 812 subjects (256 males and 556 females) who had received health examinations in 2003 participated in the study. The associations of the serum-carotenoid concentrations and HOMA-IR were evaluated cross-sectionally. The multivariate-adjusted geometric means of HOMA-IR by the tertiles of the serum carotenoid concentration were calculated after adjusting for age, body mass index, systolic blood pressure, total cholesterol, triacylglycerols, current tobacco use, regular alcohol intake, exercise habits and total energy intake. Associations among high HOMA-IR (3.0+ mU×mmol/L2) across tertiles of serum carotenoid concentration were assessed by tests for logistic regression analysis.<br>RESULTS: In male subjects, the multivariate adjusted geometric mean of HOMA-IR was inversely associated with the serum β-cryptoxanthin concentrations. In female subjects, an inverse association of the serum carotenoid concentration and HOMA-IR was observed in lycopene, β-cryptoxanthin, and zeaxanthin. The confounding factor-adjusted odds ratios (OR) for high HOMA-IR on the highest tertiles of serum α-carotene, β-carotene, β-cryptoxanthin, and zeaxanthin were 0.18 [95% confidence interval (CI): 0.06-0.52], 0.22 (95% CI: 0.07-0.67), 0.34 (95% CI: 0.12-0.96), and 0.30 (95% CI: 0.11-0.79), respectively, in male subjects. On the other hand, in female subjects, the adjusted OR for high HOMA-IR on the highest tertiles of serum lycopene and β-cryptoxanthin were 0.39 (95% CI: 0.21-0.73) and 0.51 (95% CI: 0.28-0.95), respectively.<br>CONCLUSIONS: The serum antioxidant carotenoids were inversely associated with HOMA-estimated insulin resistance in non-diabetic subjects.<br>J Epidemiol 2006; 16: 71-78.

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