Three Novel Single Nucleotide Polymorphisms of the Human Thiopurine S-Methyltransferase Gene in Japanese Individuals
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- SASAKI Takamitsu
- Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
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- GOTO Emi
- Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
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- KONNO Yumiko
- Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
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- HIRATSUKA Masahiro
- Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
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- MIZUGAKI Michinao
- Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
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Abstract
In this study, the entire coding sequence and the exon-intron junctions of the thiopurine S-methyltransferase (TPMT) gene from 200 Japanese individuals were screened for mutation. Three novel single nucleotide polymorphisms (SNPs) were identified-106G>A in exon 3 (Gly36Ser, *20 allele), 967A>G in 3′-untranslated region, and -87C>T in intron 8. The allele frequencies were 0.003 for 106G>A, 0.003 for 967A>G, and 0.010 for IVS8 -87C>T. In addition, the three known SNPs, 474T>C (Ile158Ile), 719A>G (Tyr240Cys, *3C allele), and IVS4 +35C>T were detected at frequencies of 0.299, 0.010, and 0.421, respectively.<br>
Journal
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- Drug Metabolism and Pharmacokinetics
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Drug Metabolism and Pharmacokinetics 21 (4), 332-336, 2006
The Japanese Society for the Study of Xenobiotics
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Details 詳細情報について
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- CRID
- 1390282680155473024
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- NII Article ID
- 10018043009
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- NII Book ID
- AA1162652X
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- ISSN
- 18800920
- 13474367
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed