Ｖａｌｐｒｏａｔｅ　ｓｏｄｉｕｍ長期服用中に多嚢胞卵巣症候群と肝細胞腺腫を生じた女性例

DOI PubMed 被引用文献1件 参考文献20件

書誌事項

タイトル別名
  • Polycystic Ovary Syndrome and Hepatocellular Adenoma Related to Long-Term Use of Sodium Valproate in a Young Woman

この論文をさがす

抄録

Previous studies have reported a high prevalence of polycystic ovary syndrome (PCOS) among women taking sodiumvalproate (VPA). We report the case of a 28 year-old epileptic female taking VPA, who developed PCOS and later hepatocellular adenoma. She had been taking VPA for intractable epilepsy since the age of 15 months. At the age of 22 years, she suffered spontaneous rupture of a liver tumor that was diagnosed as hepatocellular adenoma. At the age of 24 years, bilateral polycystic ovaries were found by transabdominal ultrasonography, and PCOS was diagnosed. VPA may directly influence steroidogenesis in the ovary and cause hyperandrogenemia with ensuing PCOS. It is known that abnormality in the sex hormones contributes to the onset of hepatocellular adenoma. Therefore, we speculate that hyperandrogenemia due to VPA contributed to the development of hepatocellular adenoma in this case

収録刊行物

  • 脳と発達

    脳と発達 38 (3), 205-208, 2006

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

被引用文献 (1)*注記

もっと見る

参考文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ