Design of Poly(Lactic-co-glycolic Acid) (PLGA) Nanosphere for Developing to DDS

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  • PLGAナノスフェアの設計とDDSへの展開

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Abstract

<p>PLGA nanosphere was firstly prepared by polymeric spherical crystal crystallization method (1993), which has been developed by modifying the spherical crystallization process (1982) with polymer introduced. Biodegradable properties of PLGA nanospheres are described in terms of biological half life and degradation mechanism. The preparation method of PLGA nanosphere by polymeric spherical crystallization process, SA and ESD method, is described as well as phase separation, emulsion solvent evaporation, salting out and other methods. PLGA nanosphere was developed to locally administerd DDS, such as colon targeted DDS of tacrolimus and intra articular DDS of bethamethasone sodium phosphate. PLGA nanosphere has been further developed for peptide delivery via mucous membrane, eg oral and pulmonary administration of calcitonin and insulin. It was found that the surface modification of PLGA nanosphere with mucoadhesive polymer, i.e., chitosan improved significantly the pharmacological effect and prolonged the action. Nanocomposite system of PLGA nanosphere modified with chitosan for pulmonary delivery of insulin and calcitonin has been newly developed under NEDO's project. Dry powder inhalation (DPI) DDS of peptide with nanocomposite system has been successfully developed as a non-invasive delivery system. Further new trial for gene delivery and for preparation of nanomedical device are extensively carried out. Fucntional cosmetics with vitamin C loaded PLGA nanosphere were launched recently.</p>

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