Electrocatalytic Oxidation and Highly Selective Voltammetric Determination of L-Cysteine at the Surface of a 1-[4-(Ferrocenyl ethynyl)phenyl]-1-ethanone Modified Carbon Paste Electrode
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- RAOOF Jahan-Bakhsh
- Electroanalytical Chemistry Research Laboratory, Department of Chemistry, Faculty of Basic Science, Mazandaran University
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- OJANI Reza
- Electroanalytical Chemistry Research Laboratory, Department of Chemistry, Faculty of Basic Science, Mazandaran University
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- BEITOLLAHI Hadi
- Electroanalytical Chemistry Research Laboratory, Department of Chemistry, Faculty of Basic Science, Mazandaran University
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- HOSSEINZADEH Rahman
- Electroanalytical Chemistry Research Laboratory, Department of Chemistry, Faculty of Basic Science, Mazandaran University
書誌事項
- タイトル別名
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- Electrocatalytic Oxidation and Highly Selective Voltammetric Determination of <font size=-1>L</font>-Cysteine at the Surface of a 1-[4-(Ferrocenyl ethynyl)phenyl]-1-ethanone Modified Carbon Paste Electrode
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A carbon paste electrode (CPE) chemically modified with 1-[4-(ferrocenyl ethynyl)phenyl]-1-ethanone (4-FEPEMCPE) was employed to study the electrocatalytic oxidation of L-cysteine using cyclic voltammetry, differential pulse voltammetry and double potential step chronoamperometry as diagnostic techniques. The diffusion coefficient (D = 7.863 × 10-6 cm2 s-1) of L-cysteine was also estimated using chronoamperometry. The electron-transfer coefficient, α (= 0.40), for L-cysteine at the surface of 4-FEPEMCPE was determined using cyclic voltammetry technique. It was found that under an optimum pH (= 7.00), the oxidation of L-cysteine at the surface of such an electrode occurred at a potential of about 350 mV less positive than that of an unmodified CPE. The catalytic oxidation peak currents represented a linear dependence on the L-cysteine concentration. Linear analytical curves were obtained in the ranges of 9.0 × 10-5 - 4.9 × 10-3 M and 2.0 × 10-5 - 2.8 × 10-3 M of L-cysteine with correlation coefficients of 0.9981 and 0.9982 in cyclic voltammetry and differential pulse voltammetry, respectively. The detection limits (2 σ) were determined to be 9.9 × 10-6 M and 5 × 10-6 M with cyclic voltammetry and differential pulse voltammetry, respectively. The influences of twenty other amino acids, such as glutamine, L-glutamic acid, L-glysine, L-histidine, L-isoleucine, L-leucine, L-arginine hydrochloride, L-aspargine, L-aspartic acid, S-carboxy methyl-L-cysteine, L-methionine, L-phenyl alanine, L-proline, L-serine, L-threonine, L-cystine, cysteamine and gluthathione, on the current response of the sensor were examined. The obtained results did not show any influence on the analytical signal of L-cysteine by these amino acids (except for cysteamine). The method was also used for the selective determination of L-cysteine in patient-blood plasma and some pharmaceutical preparations by using standard addition method.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 22 (9), 1213-1220, 2006
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679232964864
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- NII論文ID
- 130004441343
- 10018064282
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- NII書誌ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 8050794
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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