A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid

• Takada Kohichi

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine Division of Diagnostic Ultrasound and Medical Electronics, Sapporo Medical University School of Medicine

• Kato Junji

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Takanashi Kunihiro

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Kawano Yutaka

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Okuda Toshinori

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Hayashi Tuyoshi

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Ishiwatari Hirotoshi

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Takahashi Sho

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Miyanishi Koji

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Sato Tsutomu

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Sato Yasushi

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Takimoto Rishu

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Kobune Masayoshi

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Takayama Tetsuji

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

• Takahashi Minoru

  Rausu National Insurance of Health Hospital

• Sasaki Aya

  Department of Clinical Pathology, Sapporo Medical University School of Medicine

• Niitsu Yoshiro

  Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

Bibliographic Information

Other Title

• ウルソデオキシコール酸投与中に自己免疫性肝炎が増悪したＰＢＣ‐ＡＩＨ　ｏｖｅｒｌａｐ症候群の１例
• 症例報告 ウルソデオキシコール酸投与中に自己免疫性肝炎が増悪したPBC-AIH overlap症候群の1例
• ショウレイ ホウコク ウルソデオキシコールサン トウヨ チュウ ニ ジコ メンエキセイ カンエン ガ ゾウオ シタ PBC AIH overlap ショウコウグン ノ 1レイ

Abstract

A 54-year-old woman diagnosed as PBC-AIH overlap syndrome had been treated with UDCA. She was admitted to our hospital due to acute exacerbation of serum transaminase levels on January, 2004. Serum IgG level was normal, but liver biopsy showed worsened AIH. Human leukocyte antigen (HLA) DR4 was positive. According to the IAHG scoring system, her score was 11 points, indicating probable AIH. The serum transaminase levels effectively decreased after administration of corticosteroid. It is suggested that HLA DR4-positive patients with PBC-AIH overlap syndrome may develop worsened AIH during UDCA treatment.<br>

Journal

• Kanzo

  Kanzo 47 (6), 304-309, 2006

  The Japan Society of Hepatology

Keywords

• primary biliary cirrhosis
• autoimmune hepatitis
• PBC-AIH overlap syndrome
• HLA-DR4

Details

• CRID: 1390001204790084224
• NII Article ID: 10018070434
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.47.304
• ISSN: 18813593
• ISSN: 04514203
• NDL BIB ID: 7950570
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7950570
• Web Site: http://www.jstage.jst.go.jp/article/kanzo/47/6/47_6_304/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006204916
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed