A case of autoimmune hepatitis with severe liver fibrosis who was effectively treated with long-term administration of cyclosporin, leading to marked improvement of liver fibrosis

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  • Takanashi Kunihiro
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Takada Kohichi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Kato Junji
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Miyanishi Koji
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Kawano Yutaka
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Ishiwatari Hirotoshi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Kogawa Takahiro
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Takayama Tetsuji
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Sato Yasushi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Niitsu Yoshiro
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Takahashi Minoru
    Rause National Insurance of Health Hospital
  • Ban Noriyoshi
    Department of Gastroenterology, Hakodate National Hospital

Bibliographic Information

Other Title
  • シクロスポリンの長期投与が奏効し，肝線維化の著明改善が得られた自己免疫性肝炎の１例
  • 症例報告 シクロスポリンの長期投与が奏効し,肝線維化の著明改善が得られた自己免疫性肝炎の1例
  • ショウレイ ホウコク シクロスポリン ノ チョウキ トウヨ ガ ソウコウ シ カン センイカ ノ チョメイ カイゼン ガ エラレタ ジコ メンエキセイ カンエン ノ 1レイ

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Abstract

Summary: A 61-year old woman, who was diagnosed as autoimmune hepatitis with severe liver fibrosis had been treated with prednisolone and ursodeoxycholic acid, was referred to our hospital due to repeated aggravation. After administration of cyclosporin, serum aminotransferase was normalized. Liver fibrosis, which was corresponded to cirrhosis at first, was significantly improved 3.5 years after cyclosporin treatment, followed by further improvement to F2 after 6.5 years. Now, she remains stable clinical presentation by continuing therapy with cyclosporin for over 7.5 years.<br>

Journal

  • Kanzo

    Kanzo 47 (5), 245-251, 2006

    The Japan Society of Hepatology

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