Drug delivery system based on transport characteristics of biological membranes Drug delivery system utilizing sugar transporter

DOI 39 References
  • Mizuma Takashi
    Department of Drug Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Science

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  • 薬物の生体膜輸送特性とＤＤＳ　　糖トランスポーターを利用したＤＤＳ

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Abstract

This review summarizes studies on drug delivery system (DDS) utilizing sugar transporter. It has been reported intestinal absorption of various monosaccharide conjugates (glycosides) via Na+/glucose cotransporter (SGLT1). Transportability and recognizability of the glycosides by SGLT1 depend on types of sugar, glycoside linkage and aglycone. Therefore, glycosides should be classified by TRN classification for DDS development. Transportability of β-glucoside is the highest among glycosides. Monosaccharide conjugates such as β-glucoside should work as a prodrug, which can be transported by SGLT1. Moreover, disaccharide conjugates have potential as a pre-prodrug.<br>On the other hand, it has not been reported clear evidence for sugar transporter-mediated delivery of glycosides to brain and kidney.

Journal

  • Drug Delivery System

    Drug Delivery System 21 (2), 126-133, 2006

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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