Squamous Cell Carcinoma In Situ of the Anal Canal with Human Papillomavirus (HPV) 16 infection-Report of a Case

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  • Human Papillomavirus(HPV)16感染をともなった肛門管扁平上皮内癌の1例

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Abstract

A 65-year old woman was referred to our hospital because of hematochezia. Colonoscopy revealed a flat elevated lesion, 15mm in diameter, that was reddish with contact-bleeding, at the dentate line on the posterior wall of the lower rectum (Rb) to the anal canal. Detailed observation by a closed view after indigo carmine dye spraying clearly demonstrated a villous surface structure and remarkable vessel overgrowth making a tumor that varied in size and shape. Transanal resection was performed under spinal anesthesia. The final histological diagnosis of the resected lesion was poorly differentiated squamous cell carcinoma in situ. The polymerase chain reaction (PCR) method detected human papilloma virus (HPV) 16, which is thought to be one of the most oncogenic HPV types.

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