High-Speed and High-Sensitive Immunochemical Detection using Pillar Arrays

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  • 微細形状を利用した高速高感度免疫化学検出
  • ビサイ ケイジョウ オ リヨウ シタ コウソク コウカンド メンエキ カガク ケンシュツ

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Abstract

Enzyme-linked Immunosorbent Assay (ELISA) process is widely used for diagnosis, measurement of environmental materials, foods and so on, because of its extreme sensitivity for antigen-antibody reaction. This process, however, requires a long reaction time. We were able to shorten the reaction time required to less than 1 hour, which originally took several to more-than-ten hours, by widely enlarging the reaction area / volume with fabricating fine pillar arrays. Our process will show the possibility for instant diagnosis and instant medical treatment.<br>Moreover, ELISA process also requires dilution or enrichment of samples beforehand when the concentration of samples is unpredictable because the measurable concentration range is narrow. By changing the reaction area from a vessel to a channel, our device had a larger measurable area which made it possible to detect drastically a wider range of sample concentrations.

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