半側空間無視の脳循環代謝病態に関する研究―半側空間無視の出現と回復における両側大脳半球の係わりについて―

• 加藤 陽久

  東京医科大学第三内科 秋田県立脳血管研究センター神経内科

書誌事項

タイトル別名

• Cerebral perfusion and metabolism in relation to the evolution of unilateral spatial neglect due to cerebral infarction-Contribution of bilateral hemispheres in appearance and recovery-
• Contribution of bilateral hemispheres in appearance and recovery
• 半側空間無視の出現と回復における両側大脳半球の係わりについて

抄録

To investigate the mechanisms underlying the evolution of unilateral spatial neglect (USN) due to cerebral infarction, the cerebral oxygen metabolism was measured quantitatively by positron emission tomography (PET). Out of 189 consecutive patients with right hemisphere lesions who underwent PET, we recruited 13 patients (group A) who exhibited USN at the time of PET examination, 11 patients (group B) who had already recovered from USN, and 27 patients (group C) with right hemisphere infarction who failed to present with USN throughout. Eight normal volunteers (group NV) served as controls. Statistical comparisons were performed on the local values of the cerebral metabolic rate of oxygen (CMRO₂) from the region of interest (ROI) in the right dorsolateral frontal lobe, superior temporal gyrus, inferior parietal lobule, cingulate gyrus, basal ganglia and thalamus which are associated with USN. We also obtained CMRO₂ values for the contralateral areas. As compared with group C or NV, there were significant decreases in CMRO2 in the right frontal, right temporal and right parietal lobes, right basal ganglia, right thalamus and bilateral cingulate gyri in groups A and B. Except for the left inferior parietal lobule, no significant differences in regional CMRO₂ were noted between groups A and B. These findings indicate that extensive right hemisphere lesions may produce USN, but no specific brain region is associated with its recovery. Different from aphasics, no definite relationship is evident between recovery from USN and the role of the contralateral left hemisphere. This could be explained partly by the complexity of the pathogenetic mechanisms underlying USN.

収録刊行物

• 脳卒中

  脳卒中 28 (2), 269-279, 2006

  一般社団法人 日本脳卒中学会

キーワード

• Unilateral spatial neglect
• Right hemisphere
• Cerebral infarction
• Positron emission tomography
• Cerebral metabolic rate of oxygen

詳細情報

• CRID: 1390001204640236032
• NII論文ID: 130003439201
• NII論文ID: 10018200267
• NII書誌ID: AN0020186X
• DOI: 10.3995/jstroke.28.269
• ISSN: 18831923
• ISSN: 09120726
• Web Site: https://search.jamas.or.jp/link/ui/2006316409
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可