Detection of Multiple Types of Human Papillomavirus in a Patient with Bowenoid Papulosis and Planter Warts

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  • 複数のヒト乳頭腫ウイルス感染が検出できたボーエン様丘疹症および足底疣贅合併例
  • フクスウ ノ ヒト ニュウトウ シュ ウイルス カンセン ガ ケンシュツ デキタ ボーエン ヨウ キュウシンショウ オヨビ ソクテイ ユウゼイ ガッペイレイ

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Abstract

We report a 51-year-old woman with a more than ten year history of pigmented papules on her genital region and hyperkeratotic white papules on the soles of both feet. She had undergone gastrectomy, chemotherapy and radiation therapy for malignant lymphoma of the stomach three years previously. When she visited our department, we observed numerous papules on the soles and erythema and erosin on the genital region. The histopathological findings showed irregular acanthosis, clumping cells, and dyskeratoic cells in the epidermis in the genital lesions and vacuolization of keratinocytes in the soles. From these findings, we made a diagnosis of bowenoid papulosis and planter warts. From a biopsy of the cervix, she was also diagnosed with cervical dysplasia. Using polymerase chain reaction (PCR), we detected human papillomavirus (HPV) types -16, 70, and 91 in the genital lesions, HPV-16 and 91 in the cervix, and HPV-4 and 63 in the soles. It is rare for bowenoid papulosis, planter warts, and cervical dysplasia to be present in one patient. In this patient, we detected multiple HPV types in each lesion. As HPV 16 is known to be a high risk carcinogenic, mucosal, membranous type of HPV, we consider that simple vulvectomy and hysterectomy is needed for this patient.

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