Glycoprotein Isolated From Ulmus davidiana NAKAI Protects Against Carbon Tetrachloride-Induced Liver Injury in the Mouse

• Ko Jeong-Hyeon

  #521, Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University, Korea

• Lim Kye-Taek

  #521, Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University, Korea

書誌事項

タイトル別名

• Glycoprotein Isolated From Ulmus davidiana N<sc>AKAI</sc> Protects Against Carbon Tetrachloride-Induced Liver Injury in the Mouse

抄録

Ulmus davidiana NAKAI (UDN) has traditionally been used for healing of inflammatory diseases. This study was carried out to investigate the hepatoprotective effect of the glycoprotein isolated from UDN in carbon tetrachloride (CCl₄)-induced liver injury. We evaluated the activities of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), thiobarbituric acid-reactive substances (TBARS), and antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)] activities in CCl₄-treated mice. When mice were treated with CCl₄ in the absence of UDN glycoprotein, the activities of ALT, LDH, and TBARS were increased, while the antioxidant enzymes activities were decreased. However, when the mice were treated with CCl₄ in the presence of UDN glycoprotein, the activities of ALT, LDH, and TBARS were significantly reduced and SOD, CAT, and GPx activities were remarkably increased. In addition, UDN glycoprotein increased the nitric oxide production and decreased the nuclear factor-kappa B and activator protein-1 activation in CCl₄-treated mice. We also investigated the protective effects of UDN glycoprotein in glucose/glucose oxidase (G/GO)-induced cytotoxicity in primary cultured mouse hepatocytes. UDN glycoprotein markedly inhibited the cell death induced by G/GO. These results suggest that UDN glycoprotein protects against CCl₄-induced liver injury in the mouse.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 101 (3), 205-213, 2006

  公益社団法人 日本薬理学会

キーワード

• <i>Ulmus davidiana</i> N<font size = "-2">AKAI</font> glycoprotein
• antioxidant enzyme
• nitric oxide
• nuclear factor-kappa B
• activator protein-1

詳細情報

• CRID: 1390282680154162688
• NII論文ID: 10018236874
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.fp0051053
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 7985567
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7985567
• Web Site: https://search.jamas.or.jp/link/ui/2007131718
• 本文言語コード: en
• データソース種別:
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