Analysis of Cardioprotective Effects Using Purified Salvia miltiorrhiza Extract on Isolated Rat Hearts

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著者

    • NING Li
    • Department of Pharmacology, Faculty of Medicine, National University of Singapore
    • WANG Zhong Jing
    • Department of Pharmacology, Faculty of Medicine, National University of Singapore
    • ON Todd
    • Department of Pharmacology, Faculty of Medicine, National University of Singapore
    • DUAN Wei
    • Department of Biochemistry, Faculty of Medicine, National University of Singapore
    • ZHU Yi Zhun
    • Department of Pharmacology, Faculty of Medicine, National University of Singapore

抄録

The purpose of the current study is to evaluate the cardioprotective effects of purified <i>Salvia miltiorrhiza</i> extract (PSME) on myocardial ischemia/reperfusion injury in isolated rat hearts. Hearts were excised and perfused at constant flow (7 – 9 ml · min<sup>−</sup><sup>1</sup>) via the aorta. Non-recirculating perfusion with Krebs-Henseleit (KH) solution was maintained at 37°C and continuously gassed with 95% O<sub>2</sub> and 5% CO<sub>2</sub>. KH solution with or without PSME (100 mg per liter solution) was used after 30-min zero-flow ischemia for the PSME and control group, respectively. Left ventricular (LV) developed pressure; its derivatives, diastolic pressure, and so on were continuously recorded via a pressure transducer attached to a polyvinylchloride balloon that was placed in the left ventricle through an incision in the left atrium. PSME treated hearts showed significant postischemic contractile function recovery (developed pressure recovered to 44.2 ± 4.9% versus 17.1 ± 5.7%, <i>P</i><0.05; maximum contraction recovered to 57.2 ± 5.9% versus 15.1 ± 6.3%, <i>P</i><0.001; maximum relaxation restored to 69.3 ± 7.3% versus 15.4 ± 6.3%, <i>P</i><0.001 in the PSME and control group, respectively). Significant elevation in end-diastolic pressure, which indicated LV stiffening in PSME hearts might have resulted from the excess high dose of PSME used. Further study will be conducted on the potential therapeutic value with lower dose of PSME on prevention of ischemic heart disease.<br>

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 101(3), 245-249, 2006-07-20

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018237054
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13478613
  • NDL 記事登録ID
    7985629
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • DOI
    10.1254/jphs.FPJ05034X
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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