Effects of Eppikahangeto, a Kampo Formula, and Ephedrae herba Against Citric Acid-Induced Laryngeal Cough in Guinea Pigs

Access this Article

Author(s)

Abstract

To evaluate the efficacy of three common antitussive <i>Kampo</i> formulas, <i>eppikahangeto</i> (EPP), <i>bakumondoto</i> (BAK), and <i>shoseiryutogomakyokansekito</i> (SGM), a new cough model of guinea pig was used, which could specifically induce a laryngeal cough by microinjection of citric acid solution into the larynx. <i>Kampo</i> extract was dissolved in water and the animals were given access ad libitum for 3 days, and then the number of coughs during 10 min was counted. EPP extract decreased the number of coughs dose-dependently (0.3% extract, −22.9 ± 6.6%, <i>P</i><0.01; 1.0% extract, −32.4 ± 5.5%, <i>P</i><0.01). BAK extract and SGM extract had no significant effect. Intraperitoneal injection of codeine (60 mg/kg) also decreased the number of coughs (−36.1 ± 9.1%, <i>P</i><0.05). Furthermore, <i>Ephedrae herba</i> (EH) extract reduced the number of coughs (−18.3 ± 6.0%, <i>P</i><0.05), but the extract of EPP without EH did not. These results suggest that EPP has an antitussive effect against laryngeally-induced cough in guinea pigs, and the crucial herbal medicine is EH.<br>

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 101(2), 118-125, 2006-06-20

    The Japanese Pharmacological Society

References:  32

Cited by:  2

Codes

  • NII Article ID (NAID)
    10018237661
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13478613
  • NDL Article ID
    7963287
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top