Extracellular-Added ADP-Ribose Increases Intracellular Free Ca〔2+〕 Concentration Through Ca〔2+〕 Release From Stores, but Not Through TRPM2-Mediated Ca〔2+〕 Entry, in Rat β-Cell Line RIN-5F

DOI Web Site 被引用文献3件 参考文献20件
  • Ishii Masakazu
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, Japan
  • Shimizu Shunichi
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, Japan
  • Hagiwara Tamio
    Department of Biochemistry, Showa University School of Medicine, Japan
  • Wajima Teruaki
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, Japan Laboratory of Molecular Biology, Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan
  • Miyazaki Akira
    Department of Biochemistry, Showa University School of Medicine, Japan
  • Mori Yasuo
    Laboratory of Molecular Biology, Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan
  • Kiuchi Yuji
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, Japan

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タイトル別名
  • Extracellular-Added ADP-Ribose Increases Intracellular Free Ca2+ Concentration Through Ca2+ Release From Stores, but Not Through TRPM2-Mediated Ca2+ Entry, in Rat .BETA.-Cell Line RIN-5F
  • Extracellular Added ADP Ribose Increases Intracellular Free Ca 2 Concentration Through Ca 2 Release From Stores but Not Through TRPM2 Mediated Ca 2 Entry in Rat ベータ Cell Line RIN 5F
  • Extracellular-Added ADP-Ribose Increases Intracellular Free Ca2+ Concentration Through Ca2+ Release From Stores, but Not Through TRPM2-Mediated Ca2+ Entry, in Rat β-Cell Line RIN-5F

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Intracellular ADP-ribose is an activator of TRPM2, which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat β-cell line RIN-5F. We examined the effect of extracellular-added ADP-ribose on intracellular Ca2+ concentration in RIN-5F cells. ADP-ribose induced Ca2+ release from the thapsigargin-sensitive Ca2+ store, but not Ca2+ entry across the plasma membrane. A phospholipase C (PLC) inhibitor and a non-specific IP3 receptor inhibitor blocked its Ca2+ release. H2O2-induced Ca2+ entry through TRPM2 was not affected by extracellular ADP-ribose. These findings suggest that extracellular-added ADP-ribose induces Ca2+ release through the PLC-IP3 pathway and does not act as a TRPM2 activator.<br>

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