Molecular Pathopharmacology of 5-HT2C Receptors and the RNA Editing in the Brain

• Tohda Michihisa

  Institute of Natural Medicine, University of Toyama, Japan

• Nomura Michio

  Department of Psychology, Tokai Women’s University, Japan

• Nomura Yasuyuki

  Yokohama College of Pharmacy, Japan

抄録

Among the 14 kinds of serotonin (5-hydroxytryptamine, 5-HT) receptor subtypes (5-HTR), 5-HT_2C receptor (5-HT2CR) has been intensively investigated because of its physiologically and pathophysiologically important role in the brain. 5-HT2CR has been suggested to be involved in depressive disorders based on findings from pharmacological/neurochemical/behavioral studies using autopsy preparations of humans suffering from depression, animal models of depression, and animals treated with antidepressant drugs. Recently the editing of 5-HT2CR mRNA has been reported to participate in the pathogenesis of depressive disease. The RNA editing of 5-HT2CR induced by the presumable alteration of deaminase during a pathological state in depression causes changes of a base to another base (e.g., adenosine to guanosine, cytidine to uracil (thymidine)), followed by changes in amino acids constituting the second intracellular transmembrane loop that couples G proteins. Thus 5-HT2CR receptor-mediated signal transduction is changed. In the present review, the pathopharmacological significance of 5-HT2CR in special reference to RNA editing of receptors is reviewed and discussed from the aspect of development of novel therapeutics for depression.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 100 (5), 427-432, 2006

  公益社団法人 日本薬理学会

キーワード

• 5-HT_2C receptor
• RNA editing
• depression
• antidepressant

詳細情報

• CRID: 1390282680153798912
• NII論文ID: 10018238768
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.cpj06005x
• COI: 1:STN:280:DC%2BD28zot1amuw%3D%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 7963191
• PubMed: 16799258
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7963191
• Web Site: https://search.jamas.or.jp/link/ui/2006285428
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可