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- Miyazaki Shunichi
- Department of Physiology, Tokyo Women’s Medical University School of Medicine, Japan
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- Ito Masahiko
- Department of Physiology, Tokyo Women’s Medical University School of Medicine, Japan
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抄録
A dramatic increase in intracellular Ca2+ concentration ([Ca2+]i) occurs in eggs at fertilization common to all animal species examined to date, and this serves as a pivotal signal for egg activation characterized by resumption of meiotic cell division and formation of the pronuclei. In mammalian eggs, repetitive [Ca2+]i rises (Ca2+ oscillations) each of which accompanies a propagating wave across the egg occur due to release of Ca2+ from the endoplasmic reticulum mainly through type 1 inositol 1,4,5-trisphosphate (IP3) receptor. Ca2+ oscillations are induced by a cytosolic sperm factor driven into the egg cytoplasm upon sperm-egg fusion. A current strong candidate of the sperm factor is a novel sperm-specific isozyme of phospholipase C (IP3-producing enzyme), PLCζ. Recent extensive research has reveled characteristics of PLCζ such as the Ca2+ oscillation-inducing activity after injection of PLCζ-encoding RNA or recombinant PLCζ into mouse eggs, extremely high Ca2+-sensitivity of the enzymatic activity in vitro, and nuclear translocation ability possibly related to cell-cycle-dependent regulation of Ca2+ oscillations. [Ca2+]i rises cause successive activation of calmodulin-dependent kinase II and E3 ubiquitin ligase, lead to proteolysis of ubiquitinated cyclin B1 and inactivation of metaphase-promoting factor (Cdk1/cyclin B1 complex), and result in the release of eggs from meiotic arrest.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 100 (5), 545-552, 2006
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680153813248
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- NII論文ID
- 10018239681
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
- http://id.crossref.org/issn/13478613
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- NDL書誌ID
- 7963320
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 使用不可