Effect of Cyclosporin A on Immediate Early Gene in Rat Global Ischemia and Its Neuroprotection
-
- Yamaguchi Tatsuo
- Department of Anesthesiology, Tokyo Medical University, Japan
-
- Miyata Kazuto
- Department of Anesthesiology, Tokyo Medical University, Japan
-
- Shibasaki Futoshi
- Department of Molecular Cell Physiology, Tokyo Metropolitan Institute of Medical Science, Japan
-
- Isshiki Atushi
- Department of Anesthesiology, Tokyo Medical University, Japan
-
- Uchino Hiroyuki
- Department of Anesthesiology, Tokyo Medical University, Japan Department of Anesthesiology, Hachioji Medical Center, Tokyo Medical University, Japan
Search this article
Abstract
The expressions of the immediate early genes, c-fos and c-jun, and their product proteins C-FOS, C-JUN, and P-JUN were examined in the hippocampal CA1 subfield after global ischemia and reperfusion in rats treated with cyclosporin A. More than 90% neuronal cell death was seen in hippocampal CA1 7 days after global ischemia in control animals, but only 5% cell death after ischemia was seen in the CsA-treated animals. The expressions of c-fos and c-jun mRNA in the control animals were detected with an increase from 1 to 48 h after ischemia. On the other hand, they showed significant suppression in the CsA-treated animals. Increased expressions of C-FOS were found 1, 24, and 48 h after reperfusion in the control animals. In the CsA-treated animals C-FOS expression was found to increase, but the expression level reduced to a statistically insignificant level within 48 h after the ischemia. C-JUN and P-JUN expressions increased in control animals, but were almost completely suppressed in the CsA-treated animals. The present study demonstrated that the suppressant effects of CsA on IEGs and their products might have causal relationship to the dramatic protecting effect of the drug against delayed neuronal cell death.<br>
Journal
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 100 (1), 73-81, 2006
The Japanese Pharmacological Society
- Tweet
Details 詳細情報について
-
- CRID
- 1390001205175296256
-
- NII Article ID
- 10018241202
-
- NII Book ID
- AA11806667
-
- ISSN
- 13478648
- 13478613
-
- NDL BIB ID
- 7783054
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed