Fatty liver detected by ultrasonography is associated with the increase of brachial-ankle Pulse Wave Velocity

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  • YOSHIKAWA Hiroyuki
    Seirei Social Welfare Community, Seirei Center for Health Promotion and Preventive Medicine
  • KUBO Kiminori
    Seirei Social Welfare Community, Seirei Center for Health Promotion and Preventive Medicine
  • OHEDA Hiroshi
    Seirei Social Welfare Community, Seirei Center for Health Promotion and Preventive Medicine

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  • 上腕・足首脈波伝播速度からみた動脈硬化における脂肪肝の関与
  • ジョウ ワン アシクビ ミャクハ デンパ ソクド カラ ミタ ドウミャク コウカ ニ オケル シボウ カン ノ カンヨ

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Abstract

Fatty liver (FL) is frequently associated with obesity, insulin resistance, and dyslipidemia, but relationship between FL and atherosclerosis remains unclear. The present study was designed to determine the role of FL in the development of atherosclerosis by investigating brachial-ankle pulse wave velocity (baPWV). A study population of 872 subjects without hepatitis B and C infection and with mean daily alcohol consumption of <20g/day was available for the present analysis. The prevalence of FL detected by ultrasound was 32.6% in male and 15.2% in female. In male and female, baPWV levels in FL group were higher than those in normal (N) group (male: FL1449±277cm/sec, N1433±274cm/sec, female: FL1468±236cm/sec, N1353±244cm/sec). In both male and female, individuals with FL had more often clinical feature of metabolic disorder, for example glucose intolerance, obesity, and dyslipidemia, than persons without FL. In logistic regression analysis adjusted for age, hypertension, and smoking habit, FL was associated with the increase of baPWV (male: OR 1.63; 95%C. I. 1.04-2.56, female: OR 2.11; 95%C. I. 1.06-4.18). baPWV was significantly associated with FL and metabolic change, especially in females. The present study suggests that FL is associated with clinical features of metabolic syndrome, resulting in progression of atherosclerosis.

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