Role of Thrombogenic Factors in the Development of Atherosclerosis

• Marutsuka Kousuke

  Pathology Division, Miyazaki Medical College Hospital, University of Miyazaki, Miyazaki, Japan

• Hatakeyama Kinta

  First Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

• Yamashita Atsushi

  First Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

• Asada Yujiro

  First Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

Abstract

Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis.

Journal

• Journal of Atherosclerosis and Thrombosis

  Journal of Atherosclerosis and Thrombosis 12 (1), 1-8, 2005

  Japan Atherosclerosis Society

Keywords

• Thrombotic factors
• Atherogenesis
• Tissue factor
• PAR2

Details

• CRID: 1390282679409827328
• NII Article ID: 10018366144
• NII Book ID: AA11018976
• DOI: 10.5551/jat.12.1
• COI: 1:CAS:528:DC%2BD2MXjvFKqur4%3D
• ISSN: 18803873
• ISSN: 13403478
• ISSN: http://id.crossref.org/issn/13403478
• PubMed: 15725689
• Web Site: https://www.jstage.jst.go.jp/article/jat/12/1/12_1_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005272337
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed