Hyper-homocysteinemia is Not a Main Feature of Juvenile Uncomplicated Type 1 Diabetes

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  • Meloni Gian Franco
    Department of Pharmacology, Ginecology and Obstetrics, Pediatrics, University of Sassari, Sassari, Italy
  • Tonolo Gian Carlo
    Diabetology Unit, Department of Clinica Medica and Patologia Medica, University of Sassari, Sassari, Italy
  • Zuppi Cecilia
    Department of Clinical Chemestry, Catholic University, Rome, Italy
  • Zappacosta Bruno
    Center for High Technology Research and Education in Biomedical Science, Catholic University, Campobasso, Italy
  • Musumeci Salvatore
    Department of Pharmacology, Ginecology and Obstetrics, Pediatrics, University of Sassari, Sassari, Italy Institute of Population Genetics, C.N.R., Alghero, Sassari, Italy

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Total plasma homocysteine (tHcy) was measured by high pressure liquid chromatography (HPLC) method in 28 patients (12 females and 16 males) at the onset of type 1 diabetes mellitus (T1DM), 4 females during diabetes ketoacidosis (DKA) and 154 (68 females and 86 males) during follow-up. Serum folate, pyridoxal 5’ phosphate (PLP) and Vitamin B12 (Vit B12) were also measured. Plasma tHcy levels were not found significantly different in T1DM patients known to have diabetes (males 9.2 ± 7.7 and females 7.0 ± 2.8 μmol/l) and in those who were newly diagnosed (males 9.7 ± 4.8 and females 7.16 ± 2.8 μmol/l) than in healthy controls (males 8.7 ± 3.5 and females 7.8 ± 2.55 μmol/l). Only a significant difference for sex was observed in known diabetes (p = 0.0281). Serum folate, PLP and Vit B12 were normal (12.6 ± 3.6 ng/ml, 20.11 ± 0.8 ng/ml and 416.7 ± 41.9 pg/ml) in all T1DM patients. Age significantly correlated with plasma tHcy. Only in 4 patients, studied during DKA, plasma tHcy was significantly lower (2.76 ± 1.33 μmol/l, p < 0.001) than the healthy controls.

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