生薬粉末の製剤化―流動層造粒法による生薬顆粒より製した生薬錠剤について―

• 小西 興

  名城大学薬学部

• 砂田 久一

  名城大学薬学部

• 米澤 頼信

  名城大学薬学部

• 檀上 和美

  名城大学薬学部

書誌事項

タイトル別名

• Pharmaceutical Manufacturing of Crude Drug Powder―Crude Drug Tablets Made from Granules Prepared by Fluidized Bed Granulation―

抄録

We reported previously the granulation of Powdered Senna Leaf by the fluidized bed granulation method (J. Pharm. Sci. Technol., Jpn., 66, 457-463, 2006). In this study, we investigated the effect of physical properties of the granules on tableting in terms of hydroxy propyl cellulose (HPC) binder solution, tensile strength, friability, disintegration and dissolution rate. The relationships among those properties were analyzed by multiple regression analysis and given by correlative equations. They would give useful information for the manufacturing of crude drug tablets that show desirable properties once the granulation and tableting operation have been experimentally done.

収録刊行物

• 薬剤学

  薬剤学 66 (6), 464-472, 2006

  公益社団法人 日本薬剤学会

キーワード

• fluidized bed granulation
• crude drug
• Powdered Senna Leaf
• tableting
• binder solution
• multiple regression analysis

詳細情報

• CRID: 1390845713060921984
• NII論文ID: 10018400556
• NII書誌ID: AN00266708
• DOI: 10.14843/jpstj.66.464
• ISSN: 21883149
• ISSN: 03727629
• Web Site: https://search.jamas.or.jp/link/ui/2007028534
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可