INFLUENCE OF THYMIDINE PHOSPHORYLASE EXPRESSION ON RESPONSE TO ANTI-TUMOR AGENTS IN ORAL SQUAMOUS CELL CARCINOMA

• YOKOO Kimiko

  Department of Oral and Maxillofacial Surgery, Tokyo Medical University

• WATANABE Masato

  Department of Oral and Maxillofacial Surgery, Tokyo Medical University

• SATOMI Takafumi

  Department of Oral and Maxillofacial Surgery, Tokyo Medical University

• MATUDA Kenichi

  Department of Oral and Maxillofacial Surgery, Tokyo Medical University

• TUZUKI Masako

  Department of Oral and Maxillofacial Surgery, Tokyo Medical University

• MATUO Akira

  Department of Oral and Maxillofacial Surgery, Tokyo Medical University

• KANEKO Tadayoshi

  Department of Oral and Maxillofacial Surgery, Tokyo Medical University

• CHIBA Hiroshige

  Department of Oral and Maxillofacial Surgery, Tokyo Medical University

Bibliographic Information

Other Title

• 口腔扁平上皮癌におけるＴｈｙｍｉｄｉｎｅ　Ｐｈｏｓｐｈｏｒｙｌａｓｅの発現と抗癌剤有効性への影響

Abstract

Thymidine phosphorylase (TP) is an enzyme involved in fluoropyrimidine anti-tumor agent metabolism, but little is known about the relation between TP and response to the anti-tumor agent. To examine its influence on response to anti-tumor agent, we quantified and localized TP expression using immunohistochemistry and image analysis in oral squamous cell carcinoma tissue of 31 patients before neoadjuvant chemotherapy, then assessed the influence of TP including other tumor related factors by multivariate analysis (discriminant analysis). A criterion variable was designed between the response group and the non-response group. We could significantly discriminate between the two groups. Significant explanatory variables selected for the prediction of discrimination were thymidylate synthase (TS), TP, PCNA and nuclear polymorphism. Furthermore, TS, TP and PCNA contributed to discrimination. Accuracy rate for the response group was 0.86 and that for the non-response group was 0.76. In the response group, the accuracy could be excellent. In conclusion, TP next to TS might be an important factor for predicting the response to anti-tumor agent.

Journal

• Toukeibu Gan

  Toukeibu Gan 32 (4), 434-438, 2006

  Japan Society for Head and Neck Cancer

Keywords

• oral squamous cell carcinoma
• image analysis
• discriminant analysis
• thymidine phosphorylase

Details

• CRID: 1390282680198487552
• NII Article ID: 10018452674
• NII Book ID: AA11985555
• DOI: 10.5981/jjhnc.32.434
• ISSN: 18818382
• ISSN: 13495747
• Web Site: https://search.jamas.or.jp/link/ui/2007110439
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed