Correlation among Clinicopathological Parameters of Myocardial Damage in Rats Treated with Isoproterenol
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- KURATA Masaaki
- Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc.
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- IIDAKA Takeshi
- Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc.
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- SASAYAMA Yukiko
- Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc.
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- FUKUSHIMA Tamio
- Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc.
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- SAKIMURA Masanori
- Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc.
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- SHIRAI Norimitsu
- Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc.
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Abstract
The correlation among clinicopathological parameters of myocardial damage was investigated in rats administered a single subcutaneous dose of isoproterenol at 0 (saline), 0.04, 0.4 and 4 mg/kg. Total lactate dehydrogenase (LDH), creatine kinase (CK), and their isoenzymes (LDH-1, LDH-2 and CK-MB), as well as troponin I and tropinin T, were measured 4 h after the administration of the drug. Troponin I was determined by a chemiluminescence method using Bayer Centaur and DPC Immulyze, as well as by ELISA. Troponin T was assayed semi-quantitatively using Trop T Sensitive. A high correlation was found among LDH isoenzymes, troponin I (Centaur) and troponin T. The present result provides a baseline for interpreting changes in the different parameters of myocardial damage assayed by different methods in toxicity studies.<br>
Journal
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- Experimental Animals
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Experimental Animals 56 (1), 57-62, 2007
Japanese Association for Laboratory Animal Science
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Keywords
Details 詳細情報について
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- CRID
- 1390001205044718336
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- NII Article ID
- 130000068068
- 10018453550
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- NII Book ID
- AA11032321
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- COI
- 1:CAS:528:DC%2BD2sXitVeks7k%3D
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL BIB ID
- 8598086
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- PubMed
- 17283892
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed