Activation Mechanism of Granulocyte Colony-Stimulating Factor Receptor

• TAMADA Taro

  Quantum Beam Science Directorate, Japan Atomic Energy Agency

• HONJO Eijiro

  Quantum Beam Science Directorate, Japan Atomic Energy Agency

• KUROKI Ryota

  Quantum Beam Science Directorate, Japan Atomic Energy Agency

Bibliographic Information

Other Title

• ヒト顆粒球コロニー刺激因子受容体の活性化機構
• サイキン ノ ケンキュウ カラ ヒト カリュウキュウ コロニー シゲキ インシ ジュヨウタイ ノ カッセイカ キコウ

Abstract

The crystal structure of the signaling complex of human granulocyte colony-stimulating factor (GCSF) and ligand binding region of human GCSF receptor (GCSF-R) has been determined to 2.8 Å resolution. The GCSF : GCSF-R complex formed a 2 : 2 stoichiometry via a crossover interaction between the Ig-like domains of GCSF-R and GCSF. The conformation of the complex is quite different to that between human GCSF and the CRH domain of mouse GCSF-R. This cross-over homodimerization necessary for GCSF-R activation is consistent with previously reported thermodynamic and mutational studies.

Journal

• Nihon Kessho Gakkaishi

  Nihon Kessho Gakkaishi 48 (6), 429-435, 2006

  The Crystallographic Society of Japan

Details

• CRID: 1390001204087410432
• NII Article ID: 10018467452
• NII Book ID: AN00188364
• DOI: 10.5940/jcrsj.48.429
• ISSN: 18845576
• ISSN: 03694585
• NDL BIB ID: 8629976
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8629976
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed