Effect of Exposure to High Isoflavone-Containing Diets on Prenatal and Postnatal Offspring Mice

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  • TAKASHIMA-SASAKI Kyoka
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University
  • KOMIYAMA Masatoshi
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University Center for Environment, Health and Field Sciences, Chiba University
  • ADACHI Tetsuya
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University
  • SAKURAI Kenichi
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University
  • KATO Hideo
    Nihon Bioresearch, Inc.
  • IGUCHI Taisen
    Center for Integrative Bioscience, Okazaki National Research Institutes Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency
  • MORI Chisato
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University Center for Environment, Health and Field Sciences, Chiba University Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency

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Isoflavone (IF), a type of phytoestrogen, has multiple beneficial effects, but too much phytoestrogen can have adverse effects on offspring. To examine whether chronic exposure to high IF has adverse effects on reproductive development, mice offspring were exposed to IF through dietary administration to dams during pregnancy and lactation and to the offspring directly after weaning until sacrifice. In male offspring, there was no difference between the IF group and controls; however, in female offspring in the IF group, remarkably earlier puberty and induction of multioocyte follicles on postnatal day (PND) 21 were observed. Gene expression levels of estrogen receptor β decreased in the ovary and vagina on PND 21. These results suggest that chronic exposure to higher than normal levels of IF induces alterations in the reproductive development of female mice through an estrogenic effect.

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