Effect of Benzylic Oxygen on the Cytotoxic Activity for Colon 26 Cell Line of Phenolic Lignans

• YAMAUCHI Satoshi

  Faculty of Agriculture, Ehime University

• SUGAHARA Takuya

  Faculty of Agriculture, Ehime University

• NAKASHIMA Yuki

  Faculty of Agriculture, Ehime University

• ABE Koki

  Faculty of Agriculture, Ehime University

• HAYASHI Yoshimasa

  Faculty of Agriculture, Ehime University

• AKIYAMA Koichi

  Integrated Center for Sciences, Ehime University

• KISHIDA Taro

  Faculty of Agriculture, Ehime University

• MARUYAMA Masafumi

  Faculty of Agriculture, Ehime University

抄録

The cytotoxic activity for colon 26 cell line of matairesinol, oxidized matairesinol, 9,9′-epoxylignan and oxidized 9,9′-epoxylignan were examined. (−)-Matairesinol (Mat 1) showed greatest cytotoxic activity (LC₅₀=9 μg/ml) of the lactone-type lignans. 7,7′-Oxomatairesinol having same steric configuration as that of (−)-matairesinol showed greater activity (LC₅₀=25 μg/ml) than hydroxy or mono-oxomatairesinol. The activities of 9,9′-epoxylignan and 7,7′-oxo-9,9′-epoxylignan having same steric configurations as (−)-matairesinol were weaker than that of corresponding matairesinols. Different activity levels were observed between enantiomers.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 70 (12), 2942-2947, 2006

  公益社団法人 日本農芸化学会

キーワード

• matairesinol
• cytotoxic activity
• oxidized matairesinol

詳細情報

• CRID: 1390282681453782528
• NII論文ID: 10018523805
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.60353
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 8596492
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8596492
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60353
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可