Auraptene Decreases the Activity of Matrix Metalloproteinases in Dextran Sulfate Sodium-Induced Ulcerative Colitis in ICR Mice

• KAWABATA Kyuichi

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• MURAKAMI Akira

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHIGASHI Hajime

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

Abstract

Previously we reported that auraptene was a potent suppressant for matrix metalloproteinase (MMP)-7 expression in HT-29 human colon cancer cells. In the present study, we examined the effects of auraptene on MMP-2, -7, and -9 expression in colonic mucosa from dextran sulfate sodium (DSS)-induced ulcerative colitis mice. Auraptene remarkably suppressed the DSS-induced gelatinolytic activity of MMP-7 as well as the expression of MMP-2 and -9, suggesting that it might be useful in anti-metastatic therapies via the targeting of MMPs.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (12), 3062-3065, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• matrix metalloproteinase
• auraptene
• ulcerative colitis
• dextran sulfate sodium

Details

• CRID: 1390282681453823232
• NII Article ID: 10018524287
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.60393
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 8596961
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8596961
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60393
• Web Site: https://search.jamas.or.jp/link/ui/2007144084
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed