Stereoselective Reduction of Carbonyl Compounds Using the Cell-Free Extract of the Ealthworm, Lumbricus rubellus, Novel Source of Biocatalyst

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  • ISHIHARA Kohji
    Department of Life Science, Okayama University of Science
  • NAKAJIMA Nobuyoshi
    Industry, Government, and Academic Promotional Center, Regional Cooperative Research Organization, Okayama Prefectural University

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  • Stereoselective Reduction of Carbonyl Compounds Using the Cell-Free Extract of the Earthworm, Lumbricus rubellus, as a Novel Source of Biocatalyst
  • Stereoselective Reduction of Carbonyl Compounds Using the Cell-Free Extract of the Earthworm,<i>Lumbricus rubellus</i>, as a Novel Source of Biocatalyst

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We found the reducing activity toward carbonyl compounds in the cell-free extract of the earthworm, Lumbricus rubellus. The earthworm extract had a reducing activity for keto esters in the presence of NADH or NADPH as a coenzyme. The earthworm extract reduced ethyl 3-methyl-2-oxobutanoate to the corresponding alcohol with a high enantiomeric excess (91%, R-form) at 50 °C in the presence of NADH. In particular, ethyl 2-oxoheptanoate was exclusively reduced to the corresponding (R)-hydroxyl ester with a high enantiomeric excess (>99%).

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