Effects of Fasting and Refeeding on Expression of Atrogin-1 and Akt/FOXO Signaling Pathway in Skeletal Muscle of Chicks

• NAKASHIMA Kazuki

  Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland Science

• YAKABE Yoko

  Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland Science

• YAMAZAKI Makoto

  Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland Science

• ABE Hiroyuki

  Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland Science

抄録

This experiment was conducted to study the effects of fasting and refeeding on expression of the atrogin-1 and Akt/FOXO signaling pathway in skeletal muscle of chicks. Chicks were fasted for 24 h and refed for 2 h. Atrogin-1 mRNA expression was increased by fasting, and their increment was reduced by refeeding. Phosphorylations of Akt and FOXO1 were not decreased by fasting, but, they were increased by refeeding. These results indicate that refeeding stimulates phosphorylation of Akt/FOXO, resulting in a decrease in atrogin-1 expression in skeletal muscle of chicks.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 70 (11), 2775-2778, 2006

  公益社団法人 日本農芸化学会

キーワード

• refeeding
• atrogin-1
• Akt
• FOXO
• skeletal muscle

詳細情報

• CRID: 1390001206477562112
• NII論文ID: 10018525164
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.60274
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 8560840
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8560840
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60274
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可