Isolation of a New Anti-Allergic Phlorotannin, Phlorofucofuroeckol-B, from an Edible Brown Alga, Eisenia arborea

  • SUGIURA Yoshimasa
    Department of Technology, Kanehatsu Food Co., Ltd. Laboratory of Marine Biochemistry, Graduate School of Bioresources, Mie University
  • MATSUDA Kohji
    Department of Technology, Kanehatsu Food Co., Ltd.
  • YAMADA Yasuhiro
    Department of Technology, Kanehatsu Food Co., Ltd.
  • NISHIKAWA Masashi
    Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University
  • SHIOYA Kazufumi
    Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University
  • KATSUZAKI Hirotaka
    Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University
  • IMAI Kunio
    Laboratory of Bioorganic Chemistry, Graduate School of Bioresources, Mie University
  • AMANO Hideomi
    Laboratory of Marine Biochemistry, Graduate School of Bioresources, Mie University

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  • Isolation of a New Anti-Allergic Phlorotannin, Phlorofucofuroeckol-B, from an Edible Brown Alga,<i>Eisenia arborea</i>

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Abstract

Eisenia arborea is an edible brown alga occasionally used as a folk medicine in gynecopathy in Japan. A new phlorotannin was isolated from the alga during our search for naturally occurring anti-allergic compounds from edible algae guided by the inhibitory effect on histamine release from rat basophile leukemia (RBL)-2H3 cells. The phlorotannin was called “phlorofucofuroeckol-B.” Its structure was determined by spectral analysis and chemical conversion. This paper describes the isolation, structure elucidation, and inhibitory effect of phlorofucofuroeckol-B on histamine release.

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