Vitamin K Suppresses Lipopolysaccharide-Induced Inflammation in the Rat

• OHSAKI Yusuke

  Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University

• SHIRAKAWA Hitoshi

  Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University

• HIWATASHI Kazuyuki

  Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University

• FURUKAWA Yuji

  Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University

• MIZUTANI Takeo

  ALA Research Center

• KOMAI Michio

  Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University

Abstract

Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of γ-carboxyglutamic acid from glutamic acid residues. In addition to the liver and bone, K is found in the brain, heart, kidney and gonadal tissue. However, the physiological role of K in these various organs is not yet fully understood. It is likely that K has functions other than its role as a cofactor of protein γ-glutamyl carboxylation. We used in this study the DNA microarray technique to identify the effect of K status on gene expression in the rat liver. The expression of genes involved in the acute inflammation response was enhanced in rats fed with a K-deficient diet relative to the control and K₁-supplemented diet groups. Moreover, dietary supplementation with K₁ suppressed the inflammation induced by lipopolysaccharide administration. These results indicate that orally administrated K₁ suppressed inflammation in the rat.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (4), 926-932, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• vitamin K
• DNA microarray
• inflammation
• interleukin-6

Details

• CRID: 1390282681453270016
• NII Article ID: 10018532464
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.70.926
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 7899891
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7899891
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70.926
• Web Site: https://search.jamas.or.jp/link/ui/2007004466
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed