Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-.ALPHA. Expression in Mouse Skin

• IKEDA Yasutaka

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• MURAKAMI Akira

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• NISHIZAWA Takashi

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHIGASHI Hajime

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

Bibliographic Information

Other Title

• Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-α Expression in Mouse Skin
• Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor アルファ Expression in Mouse Skin

Abstract

An anti-inflammatory triterpenoid, ursolic acid (UA), has recently been found unexpectedly to induce the release of a pro-inflammatory mediator in resting macrophages. In this study, we found that topical applications of UA to mouse skin twice a week for 2 weeks significantly enhanced mRNA expression of cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-α, whereas its effect on tumor promotion was unclear.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 70 (4), 1033-1037, 2006

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• ursolic acid
• inflammation
• cyclooxygenase
• tumor necrosis factor-α
• 12-<I>O</I>-tetradecanoylphorbol-13-acetate

Details

• CRID: 1390001206476222848
• NII Article ID: 10018532926
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.70.1033
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 7900003
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7900003
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70.1033
• Web Site: https://search.jamas.or.jp/link/ui/2007004472
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed