Reduced Expression of Perchloric Acid-Soluble Protein after Partial Hepatectomy in Rats

  • KANOUCHI Hiroaki
    Department of Biochemistry, Kawasaki Medical School
  • TAGA Masaki
    Department of Applied Clinical Dietetics, Kitasato Junior College of Health and Hygienic Sciences
  • OKAMOTO Takeaki
    Department of Biochemistry, Kawasaki Medical School
  • YAMASAKI Masao
    Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University
  • OKA Tatsuzo
    Department of Veterinary Physiology, Kagoshima University
  • YAMADA Koji
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • TONE Shigenobu
    Department of Biochemistry, Kawasaki Medical School
  • MINATOGAWA Yohsuke
    Department of Biochemistry, Kawasaki Medical School

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Abstract

We examined the expression of perchloric acid-soluble protein (PSP) during liver regeneration after partial hepatectomy (PH) in rats. Liver regeneration was almost complete at 7-d after PH. Expression of PSP protein and mRNA decreased and then gradually increased during liver regeneration. An immunohistochemical study showed that PSP is distributed in cytosol and nuclei in normal liver, but localization in the nuclei was not be recognized in the regenerated liver.

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