Advances in "Omics" Technologies for Toxicological Research
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- INADERA Hidekuni
- Department of Public Health, Faculty of Medicine, University of Toyama
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- UCHIDA Mitsuo
- Department of Public Health, Faculty of Medicine, University of Toyama
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- SHIMOMURA Akiko
- Department of Public Health, Faculty of Medicine, University of Toyama
Bibliographic Information
- Other Title
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- 毒性研究におけるゲノム技術等の現状と課題
- ドクセイ ケンキュウ ニ オケル ゲノム ギジュツ トウ ノ ゲンジョウ ト カダイ
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Abstract
Toxicology research can be applied to evaluate potential human health risks resulting from exposure to chemicals and other factors in the environment. The tremendous advances that have been made in high-throughput “omics” technologies (e.g., genomics, transcriptomics, proteomics and metabolomics) are providing good tools for toxicological research. Toxicogenomics is the study of changes in gene expression, protein and metabolite profiles, and combines the tools of traditional toxicology with those of genomics and bioinformatics. In particular, identification of changes in gene expression using DNA microarrays is an important method for understanding toxicological processes and obtaining an informative biomarker. Although these technologies have emerged as a powerful tool for clarifying hazard mechanisms, there are some concerns for the application of these technologies to toxicological research. This review summarizes the impact of “omics” technologies in toxicological study, followed by a brief discussion of future research.
Journal
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- Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)
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Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 62 (1), 18-31, 2007
The Japanese Society for Hygiene
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Details 詳細情報について
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- CRID
- 1390282681339705600
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- NII Article ID
- 10018566957
- 10018539329
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- NII Book ID
- AN00185923
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- COI
- 1:CAS:528:DC%2BD2sXivVSkt70%3D
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- ISSN
- 18826482
- 00215082
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- NDL BIB ID
- 8689395
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed