Clinical and Bacterial Analysis of Pediatric Urinary Tract Infection

  • HOSHINO Tadashi
    Division of Infectious Diseases, Chiba Children's Hospital Department of Pediatrics, Chiba University Graduate School of Medicine
  • ISHIWADA Naruhiko
    Department of Pediatrics, Chiba University Graduate School of Medicine
  • ABE Katsuaki
    Division of Infectious Diseases, Chiba Children's Hospital Department of Pediatrics, Chiba University Graduate School of Medicine
  • SAWADA Kyoko
    Division of Clinical Laboratory, Chiba Children's Hospital
  • KOHNO Yoichi
    Department of Pediatrics, Chiba University Graduate School of Medicine

Bibliographic Information

Other Title
  • 小児尿路感染症に関する臨床的・細菌学的検討
  • ショウニ ニョウロ カンセンショウ ニ カンスル リンショウテキ サイキンガクテキ ケントウ

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Abstract

We analyzed the clinical and bacterial backgrounds of 120 patients with pediatric urinary tract infection (UTI). Escherichia coli was the main pathogen recovered from 98 patients (81.7%). All causative agents isolated from 50 uncomplicated UTI cases were E. coli. Of 98 cases of E. coli UTI, 71 were treated with secondgeneration cephems, whose therapeutic effect was equal to that of third and fourth-generation cephems. MIC50 and MIC90 (μg/mL) for E.coli were as follows: cefazolin: 2, 4; cefmetazole: ≤0.52; and ceftazidime: ≤0.25, ≤0.25. Yearly decline in susceptibility was not observed, but MIC elevation for thirdgeneration cephems (≥2μg/mL) including ceftazidime was seen in six isolates. Careful monitoring of susceptibility trends is therefore necessary for appropriate antimicrobial therapy.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 81 (1), 6-11, 2007

    The Japanese Association for Infectious Diseases

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