書誌事項
- タイトル別名
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- Selective Molecular Transformation of 1, 2-Diols Based on Molecular Recognition
- 1 2 ジオール ブンシ ニンシキ ニ モトズク センタクテキ ブンシ ヘンカン ハンノウ
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On the bases of the concept that a coordination of 1, 2-diols 1 with an appropriate metal ion (Mn+) might form an activated five-membered intermediate in which the OH group is much activated than those of non-activated 1, we examined a monobenzoylation of 1 by benzoyl chloride using tin and copper ions as Mn+. As the results, the monobenzoylation of 1 was achieved with high selectivity even in the presence of monools. The monobenzoylation reactions were then applied to kinetic resolution of dl-1 and asymmetric desymmetrization of meso-1 using a chiral organotin or BOX (bisoxazoline) -CuCl2 as a catalyst. In particular, the asymmetric outcome using (R, R) -Ph-BOX-CuCl2 catalyst was promising and attractive. That is, the kinetic resolution of dl-1 (with up to >99.9% ee for monobenzoylation of hydrobenzoin), its application to a synthesis of D-inositol-1-phosphate (100% ee), the asymmetric desymmetrization of meso-1 (with up to 94% ee for monobenzoylation of meso-1, 2-hydrobenzoin and 93% ee for monocarbamoylation of meso-1, 2-cyclooctanediol), and the asymmetric desymmetrization of meso-1, 3-diols (with up to 55% ee for the monobenzoylation of ethyl 2-ethyl-2-hydroxymethyl-3-hydroxypropanoate) were achieved. Also, the method was applied to electrochemical oxidation of 1 and its asymmetric version (38% ee for the asymmetric desymmetrization of meso-hydrobenzoin and 72% ee for the kinetic resolution of dl-hydrobenzoin).
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 65 (3), 216-225, 2007
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680289722624
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- NII論文ID
- 10018578272
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BD2sXjtFOjtro%3D
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- ISSN
- 18836526
- 00379980
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- HANDLE
- 10069/16318
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- NDL書誌ID
- 8738349
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- IRDB
- NDL
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- 抄録ライセンスフラグ
- 使用不可