高機能自閉症患者における視線弁別に関する機能的MRI研究 Gaze recognition in high-functioning autistic patients : evidence from functional MRI

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Author(s)

Abstract

We examined whether patients with high-functioning autistic disorder (AD) would exhibit abnormal activation in brain regions implicated in the functioning of theory of mind (TOM) during gaze recognition. We investigated brain activity during gaze recognition in 5 patients with high-functioning AD and 9 normal subjects, using functional magnetic resonance imaging. On the gaze task, more activation was found in the left middle frontal gyrus, the right intraparietal sulcus, and the precentral and inferior parietal gyri bilaterally in controls than in AD patients, whereas the patient group showed more powerful signal changes in the left superior temporal gyrus, the right insula, and the right medial frontal gyrus. These results suggest that high-functioning AD patients have functional abnormalities not only in TOM-related brain regions, but also in widely distributed brain regions that are not normally activated upon the processing of information from another person's gaze.

Journal

  • Chiba medical journal.

    Chiba medical journal. 82(3), 139-147, 2006-06-01

    The Chiba Medical Society

References:  39

Cited by:  2

Codes

  • NII Article ID (NAID)
    10018584272
  • NII NACSIS-CAT ID (NCID)
    AN00142148
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • Journal Type
    大学紀要
  • ISSN
    03035476
  • NDL Article ID
    8006958
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z19-499
  • Data Source
    CJP  CJPref  NDL  IR 
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