Development of Technology for Prevention and Cure of Atherosclerotic Vascular Lesions by Modulating HDL Metabolism

• Yokoyama Shinji

  Biochemistry, Cell Biology and Metabolism, Nagoya City University

Bibliographic Information

Other Title

• HDLを介した動脈硬化防御治療技術開発の展望と限界
• HDL オ カイシタ ドウミャク コウカ ボウギョ チリョウ ギジュツ カイハツ ノ テンボウ ト ゲンカイ

Abstract

HDL is a strong negative risk factor for atherosclerotic disease, and perhaps more potent target to prevent and　cure the disease than LDL in Japan. However, no specific compound to raise HDL is clinically available, so that there　is no firm evidence for the clinical effect of the increase of HDL. As our knowledge of regulation of HDL metabolism　has advanced significantly in the past several years, a great effort is being made to develop such compounds, by　inhibiting catabolic reaction of HDL, and stimulating maturation and biogenesis of HDL.

Journal

• MEMBRANE

  MEMBRANE 32 (1), 2-10, 2007

  THE MEMBRANE SOCIETY OF JAPAN

Keywords

• HDL
• cholesterol
• apolipoprotein
• apoA-I
• ABCA1
• atherosclerosis

Details

• CRID: 1390001206421668608
• NII Article ID: 10018696168
• NII Book ID: AN0023215X
• DOI: 10.5360/membrane.32.2
• ISSN: 18846440
• ISSN: 03851036
• NDL BIB ID: 8662409
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8662409
• Web Site: https://www.jstage.jst.go.jp/article/membrane/32/1/32_2/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007135572
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed