Immobilized Liposome Sensor and Its Application to Membrane- Related Diseases

• Kuboi Ryoichi

  Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University

• Umakoshi Hiroshi

  Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University

• Shimanouchi Toshinori

  Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University

Bibliographic Information

Other Title

• 固定化リポソームセンサーと膜関連疾病への応用
• コテイカ リポソームセンサー ト マク カンレン シッペイ エ ノ オウヨウ

Abstract

The diseases caused by the membrane disorder or damages are categorized as the Membrane-related diseases.　Alzheimer’s disease (AD), which is one of the membrane-related diseases, has been considered to be accompanied　by the oxidative damage of the neuronal cell membrane. Amyloid β-peptide (Aβ), which is a pathological key peptide　of AD, interacts with biomembrane and this interaction has been recently paid attention from the viewpoints of　not only conformational abnormality but also the influence to biomembrane. And therefore, the modeling of biomembrane　using liposome has been desired to develop the liposome-based sensor system. In this article, we surveyed the　sensor system using liposome. Firstly, the immobilization techniques for preparation of the immobilized-liposome　sensor are surveyed. Secondary, some kinds of sensor have been introduced: (i) (metal affinity) immobilized-liposome　chromatography, (ii) immobilized-liposome quartz crystal microbalance method, (iii) immobilized-liposome　sensor (Amperometric method), (iv) membrane chip system. These techniques have been developed in a framework　of “Membrane Stress Biotechnology”. The above methodologies could provide us the quantitative properties of　stress responsive function of both the protein and the membrane.

Journal

• MEMBRANE

  MEMBRANE 32 (1), 32-39, 2007

  THE MEMBRANE SOCIETY OF JAPAN

Keywords

• membrane stress biotechnology
• liposome
• immobilized liposome sensor
• membrane-related diseases

Details

• CRID: 1390001206421669248
• NII Article ID: 10018696288
• NII Book ID: AN0023215X
• DOI: 10.5360/membrane.32.32
• ISSN: 18846440
• ISSN: 03851036
• NDL BIB ID: 8662475
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8662475
• Web Site: https://www.jstage.jst.go.jp/article/membrane/32/1/32_32/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007135576
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed