<i>In vitro</i> evaluation of cytotoxicity of resin-based root canal sealers

• Yoshito YOSHIMINE

  Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University

• Souichiro NISHIGAKI

  Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University

• Himeka MATSUMOTO

  Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University

• Makiko ONO

  Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University

• Hidefumi MAEDA

  Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University

• Akifumi AKAMINE

  Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University

Bibliographic Information

Other Title

• レジン系根管充塡用シーラーの細胞毒性に関する研究

Abstract

Abstract : The purpose of this study was to evaluate the cytocompatibility of four different types of root canal sealers in cell culture. Osteoblastic cells, MC3T3-E1, were cultured for 3 days with freshly mixed materials and set ones for 14 days from two resin-based sealers (Super-bond and AH-26), a zinc oxide-eugenol-based sealer (Canals), and a calcium hydroxide-based sealer (Sealapex). Cytotoxic effects were evaluated on the basis of the morphological changes under a light microscope. In the freshly mixed sealers, AH-26 showed the highest cytotoxicity. Super-bond and Canals were less cytotoxic, causing a slight decrease in cell density in the vicinity of the sealers. The cells adjacent to Sealapex revealed normal morphology and growth. On the other hand, in the set sealers, Super-bond and AH-26 exerted little influence on the cells and reached confluency. Canals and Sealapex showed mild cytotoxic effects.  These results suggest that the 4-META resin-based sealer, Super-bond, is a biocompatible material and has good potential as a root canal sealer.

Journal

• The Journal of Japan Endodontic Association

  The Journal of Japan Endodontic Association 28 (1), 38-44, 2007

  Japan Endodontic Association

Keywords

• root canal sealer
• biocompatibility
• cell culture
• cytotoxicity
• Super-bond

Details

• CRID: 1390001205189668992
• NII Article ID: 10018731872
• NII Article ID: 130006295355
• NII Book ID: AA11837117
• DOI: 10.20817/jeajournal.28.1_38
• ISSN: 24239429
• ISSN: 13478672
• Web Site: https://search.jamas.or.jp/link/ui/2007124659
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed