書誌事項
- タイトル別名
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- A YOUNG FEMALE BRAZILIAN WITH SICKLE CELL DISEASE WHO HAD DIFFICULTY OBTAINING COMATIBLE BLOOD FOR TRANSFUSION DUE TO MULTIPLE ALLOANTIBODIES (UNEXPECTED ANTIBODIES) AGAINST ERYTHROCYTES
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We describe an 18-year-old female Brazilian with sickle cell disease (SCD) who had a difficulty in obtaining compatible blood for transfusion because of the presence of multiple alloantibodies (unexpected antibodies) against erythrocytes. A diagnosis of SCD had been made when she was 2 years old and since then had repeated blood transfusions while in Brazil. Four days before visiting Japan, she was treated with intravenous fluid and blood transfusion due to acute alcoholic poisoning. On the day after arriving in Japan, she was admitted to our hospital because of bilateral femoral pain. Severe hemolysis was determined and blood transfusion was required. Anti-E, -M and -S alloantibodies were identified by irregular antibody screening. Although we performed compatibility testing using E, M and S antigen-negative concentrated red blood cells (CRC), only a few units of crossmatch-compatible blood were found. A blood sample from this patient was sent to the Tokyo Metropolitan Red Cross Blood Center reference lab to examine the patient's extended red blood cell (RBC) phenotype and to confirm the presence of additional alloantibodies. The patient's reticulocytes and RBCs were isolated by Percoll-Urografin density gradient centrifugation and washing with hypotonic (0.3%) saline, respectively. Her RBC phenotype was determined as O, D +, C+, c+, E-, e+, M-, N+, S-, s+, Jk (a+b+), Fy (a+b+), Pl+, Le (a-b-), Di (a-b+). Further, IgG anti-Yka alloantibody was also detected in her serum. We were able to obtain extended phenotype-matched CRC to provide blood compatible with her existing antibodies from the nationwide blood supply. We recommend both extended phenotype-matching and white blood cell reduction for transfusions to SCD patients to prevent the production of alloantibodies.
収録刊行物
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- 日本輸血細胞治療学会誌
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日本輸血細胞治療学会誌 52 (4), 501-506, 2006
一般社団法人 日本輸血・細胞治療学会
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詳細情報 詳細情報について
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- CRID
- 1390282680249699968
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- NII論文ID
- 130003707142
- 10018786015
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- NII書誌ID
- AA12159645
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- ISSN
- 18830625
- 18813011
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 使用不可