A case of malignant granular cell tumor of the mandible metastasizing from the skull base

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  • YAMBE Makoto
    Department of Dental, Oral and Maxillofacial Surgery, Komaki City Hospital
  • WATANABE Kazuyo
    Department of Oral and Maxillofacial Surgery, Nagoya Daini Red Cross Hospital
  • TOH Taketomo
    Department of Dental, Oral and Maxillofacial Surgery, Komaki City Hospital
  • TAKAHASHI Makoto
    Department of Dental, Oral and Maxillofacial Surgery, Komaki City Hospital
  • TOHNAI Iwai
    Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine
  • UEDA Minoru
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

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Other Title
  • 下顎骨に転移した頭蓋底原発悪性顆粒細胞腫の１例
  • ショウレイ ホウコク カガクコツ ニ テンイ シタ トウガイテイ ゲンパツ アクセイ カリュウ サイボウ シュ ノ 1レイ

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Abstract

A 57-year-old man underwent surgical excision of a skull base tumor in 1996, which was diagnosed as a granular cell tumor histopathologically. Gamma knife radiosurgery was performed for a recurrent tumor in 2000. A recurrent tumor developed from the right infratemporal fossa and underwent gamma knife radiosurgery againin 2001. He visited our department in 2002 because of swelling and pain in the left side of the mandible. Panoramic radiography revealed a radiolucency (35mm×50mm) with an ill-defined border in the body of the left side of the mandible. The histopathological diagnosis of a biopsy specimen was a malignant granular cell tumor. Radiosurgery with a Cyber knife was performed. Metastases to the liver and pancreas were detected during follow-up. Although adequate control of the metastatic site of the mandible was obtained, the patient died of arterial bleeding from necrotic tissue of the mandible and cachexia 10 months after radiosurgery with the Cyber knife.

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