<b>Proton MR spectroscopy study in chronic pain patients</b>

• Fukui Mikio

  Department of Anesthesiology, Pain Clinic Center, Shiga University of Medical Science

• Iwashita Narihito

  Department of Anesthesiology, Pain Clinic Center, Shiga University of Medical Science

• Iida Atsmi

  Department of Anesthesiology, Pain Clinic Center, Shiga University of Medical Science

• Tsukahara Etsuko

  Department of Anesthesiology, Pain Clinic Center, Shiga University of Medical Science

• Takeuchi Junko

  Department of Anesthesiology, Pain Clinic Center, Shiga University of Medical Science

• Matsuno Miyuki

  Department of Anesthesiology, Pain Clinic Center, Shiga University of Medical Science

• Nosaka Shuichi

  Department of Anesthesiology, Pain Clinic Center, Shiga University of Medical Science

Bibliographic Information

Other Title

• MRスペクトロスコピーを用いた慢性疼痛患者の評価の試み

Abstract

   We investigated the absolute concentration of N-acetylaspartate (NAA) in the thalamus, anterior cingulated cortex (ACC), and prefrontal cortex (PFC), in chronic pain patients by proton magnetic resonance spectroscopy (¹H-MRS).<br>   ¹H-MRS was performed with a 1.5T MR system on a voxel in the thalamus, ACC, and PFC bilaterally, in 18 chronic pain patients and 15 normal control subjects. We measured the absolute concentration of NAA using a LC-Model.<br>   The patients whose NAA concentration in the ACC or PFC decreased significantly, compared to the mean NAA concentration of the normal control subjects, needed psychological approach. ¹H-MRS suggest that NAA concentration in the ACC or PFC seems to be associated with the necessity of psychological approach.<br>   ¹H-MRS may serve as a useful non-invasive tool for evaluating neural activity of thalamus, anterior cingulated cortex, and prefrontal cortex in chronic pain patients.

Journal

• PAIN RESEARCH

  PAIN RESEARCH 22 (1), 27-33, 2007

  JAPANESE ASSOCIATION FOR STUDY OF PAIN

Keywords

• MR spectroscopy
• Proton magnetic resonance spectroscopy
• Anterior cingulated cortex
• Prefrontal cortex
• N-Acetylaspartate
• Chronic pain

Details

• CRID: 1390001204368093824
• NII Article ID: 10018864312
• NII Book ID: AN10195934
• DOI: 10.11154/pain.22.27
• ISSN: 21874697
• ISSN: 09158588
• ISSN: http://id.crossref.org/issn/09158588
• Web Site: https://www.jstage.jst.go.jp/article/pain/22/1/22_4/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007219820
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed