Historical Background of Clinical Application of .ALPHA.2 Agonists in Anesthesia

• HAYASHI Yukio

  Department of Anesthesiology, Osaka University Medical School

Bibliographic Information

Other Title

• 麻酔科医とα２アゴニスト　　α２アゴニストの基礎―歴史的背景を含めて―
• Historical Background of Clinical Application of α2 Agonists in Anesthesia

Abstract

  It is well known that α₂ agonists have various pharmacological effects, including sedation, analgesia, and sympatholysis. Since these effects are important in anesthetic management, applying α₂ agonists to clinical anesthesia has been expected. Development of dexmedetomidine, a potent and selective α₂ agonist, facilitated a clinical trial of the drug as an anesthetic adjunct in clinical anesthesia. Unfortunately, this clinical trial was interrupted. However, dexmedetomidine was introduced as a postoperative sedative drug, because it provides high-quality sedation. While we can expect that dexmedetomidine has a lot of potential in clinical anesthesia, we should be careful of side effects because of its various pharmacological actions.

Journal

• THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA

  THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 27 (2), 110-116, 2007

  THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA

Keywords

• α₂agonists
• Dexmedetomidine

Details

• CRID: 1390282679737017472
• NII Article ID: 130004449632
• NII Article ID: 10018874352
• NII Book ID: AN00330159
• DOI: 10.2199/jjsca.27.110
• ISSN: 13499149
• ISSN: 02854945
• Web Site: https://search.jamas.or.jp/link/ui/2007220648
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed