A randomized controlled trial by the 3DS for dental caries

DOI 35 References
  • Katsumura Seiko
    Department of Anatomy, Tsurumi University School of Dental Medicine
  • Nishikawara Fusao
    Department of Oral Health, National Institute of Public Health
  • Tamaki Yoh
    Department of Oral Health, National Institute of Public Health Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine Division of Oral Health, Department of Health Science, Kanagawa Dental College
  • Nakamura Yoshiki
    Department of Orthodontic, Tsurumi University School of Dental Medicine
  • Sato Keita
    Department of Forensic Medicine and Dentistry, Tsurumi University School of Dental Medicine
  • Nomura Yoshiaki
    Department of Oral Health, National Institute of Public Health Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine
  • Hanada Nobuhiro
    Department of Oral Health, National Institute of Public Health

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Abstract

The aim of this study is to evaluate the povidone-iodine for the suppression of oral cariogenic bacteria and compare its effects to that of fluoride in children. We carried out a randomized controlled trial to compare the effects of povidone-iodine to those for sodium fluoride. Pre-school children (n = 210) with more than 105 cfu/ml mutans streptococci in their stimulated saliva were randomly sampled and randomly allocated into three groups. We planned the preventive program by 3DS (Dental Drag Delivery System). The groups that provided preventive programs were the povidone-iodine group (n = 70) and the sodium fluoride group (n = 70). A control group (n = 70) received no intervention. Povidone-iodine or sodium fluoride was applied to the tooth surface using custom made trays. Subsequent home care was obligatory for one month. After one month, the salivary levels of mutans streptococci were low level when compared to the based data. However the difference in salivary levels of mutans streptococci among groups was not statistically significant when comparing the povidone-iodine group with the sodium fluoride group (P = 0.625). After 2.5 years follow up, differences in incidence of new dental caries among the three groups were not statistically significant (P = 0.583). Clinical application of anti-microbial drugs may be effective, but only a single intervention is not sufficient to reduce the incidence of new dental caries.

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