書誌事項
- タイトル別名
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- Analysis of Fluctuating Protein Structure - Approach from Variable Pressure NMR
- ユラグ タンパクシツ コウゾウ ノ カイセキ カヘン アツリョク NMR カラノ アプローチ
- - Approach from Variable Pressure NMR
- —可変圧力 NMR からのアプローチ
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抄録
Protein structure in solution fluctuates over a wide range of conformation, but the reality of the fluctuation has been little explored. In this article, we present an approach to this problem using variable pressure NMR spectroscopy. The method enables us to explore protein conformation over a wide range of conformational space than hitherto explored by conventional NMR method and brings about a new dynamic view on protein structure. The highlight of the method is the determination of the structural coordinates of semi-stable higher energy conformers that exist in low population in dynamic equilibrium with the stable "native" conformer under physiological conditions. Available evidence suggests that such high energy conformers play crucial roles in function in many proteins.
収録刊行物
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- 高圧力の科学と技術
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高圧力の科学と技術 17 (1), 32-41, 2007
日本高圧力学会
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詳細情報 詳細情報について
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- CRID
- 1390282679358844032
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- NII論文ID
- 10018918369
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- NII書誌ID
- AN10452913
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- ISSN
- 13481940
- 0917639X
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- NDL書誌ID
- 8742671
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可